Dr badhwar says mitral regurgitation or mr is a backward leakage of the central valve of the heart the mitral valve the mitral valve is a one way valve that works like a set of two french doors that meet in the middle it is made up of the doors known as leaflets and the door frame known as the annulus. The following are key points to remember from this review on secondary mitral regurgitation mr primary mitral regurgitation mr is a disease of the mitral leaflets or chords whereas secondary mr is caused by disease of the left ventricle lv or left atrium la. Secondary mitral regurgitation smr occurs when coronary disease with myocardial infarction or primary dilated cardiomyopathy cause a combination of left ventricular lv wall motion abnormalities mitral annular dilatation papillary muscle displacement and reduced closing force that prevent the mitral valve from coapting normally. Secondary mitral regurgitation smr occurs as a result of multifactorial left atrioventricular dysfunction and maleficent remodelling it is the most common and undertreated form of mitral regurgitation mr and is associated with a very poor prognosis. Secondary mitral regurgitation smr is a common occurrence in patients with heart failure with reduced ejection fraction moderate severe or severe smr is associated with increased mortality and hospitalisations from heart failure
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